Speciation of arsenic – A review of phenylarsenicals and related arsenic metabolites

Environmental and health studies of arsenic require the determination of arsenic species of diverse properties and toxicities. This review summarizes recent analytical advances in speciation of phenylarsenicals. Arsenic speciation techniques have taken advantage of high performance liquid chromatogr...

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Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2018-07, Vol.104, p.171-182
Main Authors: Liu, Qingqing, Lu, Xiufen, Peng, Hanyong, Popowich, Aleksandra, Tao, Jeffrey, Uppal, Jagdeesh S., Yan, Xiaowen, Boe, Dana, Le, X. Chris
Format: Article
Language:English
Subjects:
Arsenic toxicity
Chicken
Electrospray ionization mass spectrometry
Enzyme-assisted extraction
HPLC-ICPMS
Liquid chromatography
Mass spectrometry
Metabolite identification
Protein binding
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Summary:Environmental and health studies of arsenic require the determination of arsenic species of diverse properties and toxicities. This review summarizes recent analytical advances in speciation of phenylarsenicals. Arsenic speciation techniques have taken advantage of high performance liquid chromatography (HPLC) separation with inductively coupled plasma mass spectrometry (ICPMS) and electrospray ionization tandem mass spectrometry (ESI-MS/MS) detection. These techniques have enabled the identification and quantitation of new arsenic species. Characterization of phenylarsenical metabolites has contributed to better understanding of the fate of phenylarsenicals and the potential risk of human exposure. Binding of trivalent phenylarsenicals to proteins has facilitated the development of analytical techniques for the capture and identification of arsenic-binding proteins. [Display omitted] •Reviewed recent advances in extraction, separation, and detection of phenylarsenicals.•Illustrated advantages of complementary HPLC with ICP-MS and ESI-MS detection.•Demonstrated identification of new arsenic metabolites.•Described capture and identification of arsenic-binding proteins.•Provided perspectives on future research needs.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2017.10.006