Application of molecularly imprinted polymers in analytical chiral separations and analysis

• Published in: TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2018-05, Vol.102, p.91-102
• Main Authors: Rutkowska, Małgorzata, Płotka-Wasylka, Justyna, Morrison, Calum, Wieczorek, Piotr Paweł, Namieśnik, Jacek, Marć, Mariusz
• Format: Article
• Language: English
• Subjects: Capillary electrochromatography; Chiral separation; Enantiomers; High performance liquid chromatography; Molecularly imprinted polymers
• ISSN: 0165-9936; 1879-3142
• DOI: 10.1016/j.trac.2018.01.011

Over the last two decades the process of development and application of a new types of molecular imprinted polymer (MIP) sorbents in the field of analytical chemistry have been widely described in the literature. One of the new trends in analytical chemistry practice is the use of new types of MIP sorbents as specific sorption materials constituting the stationary phase in advanced separation techniques. The following review paper contains comprehensive information about the application of a specific and well defined MIP sorbents (with the data base in the paper about the reagents used in MIP preparation process) as stationary phases in separation techniques including high performance liquid chromatography and capillary electrochromatography. Coverage includes newly created types of stationary phases (MIP sorbents) used for chiral recognition, with the focus on applications in enantioselective separation. •The current role of MIP-type affinity materials in chiral recognition is provided.•The application of MIPs in the field of assessing the optical purity of chemical compounds is presented.•Types of MIPs used as stationary phases in separation techniques are mentioned.•Application of MIPs in enantioseparation by chromatographic techniques is discussed.•Future challenges concerning MIPs are discussed.