Nanozyme: An emerging alternative to natural enzyme for biosensing and immunoassay

• Published in: TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2018-08, Vol.105, p.218-224
• Main Authors: Wang, Qingqing, Wei, Hui, Zhang, Zhiquan, Wang, Erkang, Dong, Shaojun
• Format: Article
• Language: English
• Subjects: Biosensors; Glucose detection; Immunoassay; Nanocomposites; Nanozymes
• ISSN: 0165-9936; 1879-3142
• DOI: 10.1016/j.trac.2018.05.012

Nanozyme, a term defined for nanomaterial with enzyme-like properties, has attracted significant research attention owing to its striking merits. Recently, a surge of nanozymes have been demonstrated to catalyze some typical enzymatic reactions mimicking oxidase, peroxidase and catalase. Especially, nanozymes with peroxidase-like activity have grown into a big family due to their broad range of applications in the field of biosensing and immunoassay. Since inorganic nanoparticles possess the advantages of high stability and easy surface modification, nanozymes have been emerging alternatives to natural enzymes to some extent. In this Review, we briefly summarize several typical nanozymes and then focus our attention on their enormous applications with respect to analytical chemistry. Representative examples would be discussed in detail from the literatures of last 10 years. Additionally, the current challenges and future directions about nanozymes are speculated at the end of this review. •Several specific kinds of nanozymes were introduced.•The important role of nanozymes in the field of biosensing and immunoassay was highlighted.•Different strategies for the detection of glucose based on nanozymes were compared.•Challenges and future outlooks for the development of nanozymes were discussed.