Fabrication of fluorescent biosensing platform based on graphene oxide-DNA and their application in biomolecule detection

During the past few years, graphene oxide (GO) becomes increasingly significant in fluorescent biosensing due to its unique heterogeneous structure that offers it potential applications in various fields. Based on the transformation of affinities between GO and DNA, plenty of assays for bioanalysis...

Full description

Saved in:
Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2018-09, Vol.106, p.53-61
Main Authors: Wang, Si-Ying, Wang, Chen-Feng, Lv, Yun-Kai, Shen, Shi-Gang
Format: Article
Language:English
Subjects:
Biomolecule
DNA
Fluorescent biosensors
Graphene oxide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:During the past few years, graphene oxide (GO) becomes increasingly significant in fluorescent biosensing due to its unique heterogeneous structure that offers it potential applications in various fields. Based on the transformation of affinities between GO and DNA, plenty of assays for bioanalysis have been developed rapidly, in which GO generally functions as a quencher. In this review, the current status and design mechanism of fluorescent biosensing platform based on graphene oxide-DNA are introduced in detail; the latest research progress of biomolecular fluorescence sensing has been summarized, classified and compared in this paper. Some unique and elegant ideas are introduced. •The progress of graphene oxide-DNA fluorescence sensing platform in the detection of biomolecules is introduced.•The design strategies of fluorescence sensor are described.•The highlights, recognition mechanisms and biological applications of various sensors are compared and reviewed.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2018.07.004