Biosensors for measuring matrix metalloproteinases: An emerging research field

Matrix metalloproteinases (MMPs) have been proposed as markers of many pathological conditions for their ability to degrade extracellular matrix components and remodel tissues. This review presents an overview of biosensors for the measurement of MMPs in serum, sputum and cell cultures. Major benefi...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2019-01, Vol.110, p.35-50
Main Authors: Kirchhain, Arno, Poma, Noemi, Salvo, Pietro, Tedeschi, Lorena, Melai, Bernardo, Vivaldi, Federico, Bonini, Andrea, Franzini, Maria, Caponi, Laura, Tavanti, Arianna, Di Francesco, Fabio
Format: Article
Language:English
Subjects:
Biosensors
Electrochemical sensors
Immunoassays
Matrix metalloproteinases
Molecular probes
Optical sensors
Surface plasmon resonance
Zymography
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Summary:Matrix metalloproteinases (MMPs) have been proposed as markers of many pathological conditions for their ability to degrade extracellular matrix components and remodel tissues. This review presents an overview of biosensors for the measurement of MMPs in serum, sputum and cell cultures. Major benefits and limitations of these technologies are discussed with respect to zymography and immunoassays, which are the reference methods to measure MMP activity and concentration. The paper also compares the analytical performances of sensors to the specific requirements for the application in clinical research, and comments on future trends in this field. •Matrix metalloproteinases degrade extracellular matrix components/remodel tissues.•MMPs are involved in many physiological and pathological processes.•Overview of biosensors for the measurement of MMPs in biofluids.•Pros and cons of sensing technologies compared to zymography and immunoassays.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2018.10.027