Water-dispersed luminescent quantum dots for miRNA detection

This review targets valuable insight into the application of water dispersed luminescent quantum dots (QDs) for detection of microRNA (miRNA). Recently, considerable efforts have been devoted to obtain QDs for biosensing and bioimaging. Quantum dots with bright stable photoluminescence, synthesized...

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Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2019-02, Vol.111, p.197-205
Main Authors: Goryacheva, Olga A., Novikova, Anastasiya S., Drozd, Daniil D., Pidenko, Pavel S., Ponomaryeva, Tatiana S., Bakal, Artem A., Mishra, Pradyumna K., Beloglazova, Natalia V., Goryacheva, Irina Yu
Format: Article
Language:English
Subjects:
Electrochemiluminescence
Electrochemiluminescence energy transfer
Förster resonance energy transfer
MicroRNA
Photoluminescence
Quantum dots
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Summary:This review targets valuable insight into the application of water dispersed luminescent quantum dots (QDs) for detection of microRNA (miRNA). Recently, considerable efforts have been devoted to obtain QDs for biosensing and bioimaging. Quantum dots with bright stable photoluminescence, synthesized directly in the water phase, offered an unparalleled advantage for the assay development involving small size, high colloidal stability, and presence of groups for bioconjugation. In this review we have delineated the fundamental principles guiding the rational design, synthesis, and application of photoluminescent water-dispersed QDs. Diverse analysis methods for miRNA detection based on the photoluminescence, electrochemiluminescence, Förster resonance energy transfer and electrochemiluminescence energy transfer with different enhancement strategies are discussed. •Water-dispersed QDs' application for micro-RNA detection is reviewed.•Special focus is made on the application of DNA-templated QDs.•QDs' synthesis routes are overviewed.•The principles of the generation of analytical signals are examined.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2018.12.022