Solid Phase Microextraction-mass spectrometry: Metanoia

Although multiple investigations into the benefits of directly interfacing SPME devices to MS instrumentation for rapid analysis of complex matrices have been ongoing for over 2 decades, several external factors have contributed to keeping these developments in the shadows. Among them, one can highl...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2019-03, Vol.112, p.201-211
Main Authors: Gómez-Ríos, German A., Mirabelli, Mario F.
Format: Article
Language:English
Subjects:
Ambient ionization
Bioanalytical
Clinical diagnosis
Environmental analysis
Food analysis
Forensics
Mass spectrometry
SPME
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Summary:Although multiple investigations into the benefits of directly interfacing SPME devices to MS instrumentation for rapid analysis of complex matrices have been ongoing for over 2 decades, several external factors have contributed to keeping these developments in the shadows. Among them, one can highlight the prejudice against microextraction technologies and ambient mass spectrometry, the lack of commercially available products, and overpraising by the analytical chemistry industry in relation to other direct-sample-to-MS technologies. Despite remaining outside of the mainstream, SPME-MS technologies have been successfully applied in diverse fields including food, environmental, forensics, and clinical analysis. This mini-review provides an overview of the most thrilling advances in SPME-MS that have been documented over the last lustrum and how these innovations can be applied to challenging analytes/matrices. In addition, a humble prognosis of this exciting field is provided, including potential avenues for further exploration, as well as significant existing limitations to be overcome. [Display omitted] •New developments in SPME-MS technologies are outlined.•Advantages and drawbacks of existing SPME-MS technologies are succinctly presented.•Future directions for research and challenges to be overcome in the SPME-MS universe are discussed.•A change in the reader's perception of SPME-MS as a highly suitable analytical technology for rapid qualitative and quantitative analysis is guaranteed.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2018.12.030