Paper spray ionization: Applications and perspectives

Paper spray ionization has grown to become one of the most successful ambient ionization methods within the past decade. Requiring little to no sample preparation and being remarkably simple to construct, this technique has seen application in a wide number of fields. This review approaches the mech...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2019-09, Vol.118, p.722-730
Main Authors: McBride, Ethan M., Mach, Phillip M., Dhummakupt, Elizabeth S., Dowling, Sarah, Carmany, Daniel O., Demond, Paul S., Rizzo, Gabrielle, Manicke, Nicholas E., Glaros, Trevor
Format: Article
Language:English
Subjects:
3D printing
Ambient ionization
Clinical
Environmental
Forensic
Omics
Paper spray ionization
PS-MS
Reaction Monitoring
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Summary:Paper spray ionization has grown to become one of the most successful ambient ionization methods within the past decade. Requiring little to no sample preparation and being remarkably simple to construct, this technique has seen application in a wide number of fields. This review approaches the mechanism of how paper spray works, and seeks to better classify what it is and is not in a rapidly expanding field of ambient techniques. Additionally, many applications of the technique in clinical, forensic, environmental, and reaction monitoring regimes are explored. Finally, perspectives towards the future of how paper spray could be utilized will be expanded upon, including unexplored substrates and possibilities for the 'omics space. [Display omitted] •Paper spray has become one of the most popular ambient ionization techniques.•Significant progress has been made recently in developing methods and applications.•Herein these methods and applications are explored in a variety of research spaces.•Future efforts will include ‘omics applications and further design developments.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2019.06.028