Loading…
Nano-sized polymer and polymer-coated particles in electrokinetic separations
Capillary electrophoresis (CE) is a rapidly developing method of efficient and selective separation of charged and uncharged compounds. Application of various modifiers of the background electrolyte (BGE) and capillary walls provide enhancement of selectivity and reproducibility of CE analyses. Nano...
Saved in:
Published in: | TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2019-11, Vol.120, p.115656, Article 115656 |
---|---|
Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Capillary electrophoresis (CE) is a rapidly developing method of efficient and selective separation of charged and uncharged compounds. Application of various modifiers of the background electrolyte (BGE) and capillary walls provide enhancement of selectivity and reproducibility of CE analyses. Nanoparticles (NPs) are the most promising modifiers, primarily due to their unique surface chemistry, formation of stable suspensions in BGEs, compatibilities with organic solvents and MS detection. Polymer NPs combine the advantages of nano-sized particles and the ease of dense functionalization. The combination of these properties can be also achieved by joint application of polymers with inorganic-based NPs. Here we review recent application examples of polymer NPs and discuss various synergetic examples of simultaneous use of polymers along with inorganic NPs for the separation of wide classes of compounds. We also consider approaches to capillary modification with NPs and types of “polymer-NPs” combinations for the coating and pseudo-stationary phase formation.
•Polymer nanoparticles as capillary coatings and pseudo-stationary phases for the electrokinetic separations.•Joint application of polymers and inorganic nanoparticles for the coatings and pseudo-stationary phases formation.•Immobilization approaches for coatings based on polymer and inorganic nanoparticles formation. |
---|---|
ISSN: | 0165-9936 1879-3142 |
DOI: | 10.1016/j.trac.2019.115656 |