Trends in miniaturized biosensors for point-of-care testing

The popularization of point-of-care (POC) testing is of great importance in healthcare diagnostics and other fields in the developing world, especially in resource-limited settings. To date, there are still great challenges in the development of simple, quick, affordable, yet highly effective and se...

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Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2020-01, Vol.122, p.115701, Article 115701
Main Authors: Liu, Dan, Wang, Junxia, Wu, Lingling, Huang, Yishun, Zhang, Yuqian, Zhu, Mingyang, Wang, Yang, Zhu, Zhi, Yang, Chaoyong
Format: Article
Language:English
Subjects:
Automation
Handheld instrument
Integration
Microfluidic platform
Miniaturized biosensor
Multiplexing
Point-of-care testing
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Summary:The popularization of point-of-care (POC) testing is of great importance in healthcare diagnostics and other fields in the developing world, especially in resource-limited settings. To date, there are still great challenges in the development of simple, quick, affordable, yet highly effective and selective biosensors for POC testing. To meet the increasing need for POC testing, researchers need to consider biosensor miniaturization. In this review, we focus on recent advances in miniaturized biosensors for POC testing. We first review the miniaturization strategies, including handheld instruments and microfluidics-assisted miniaturized biosensing systems. Recent progress in recognition biosensing interactions for miniaturized biosensing systems is then summarized. We further describe how POC testing applications can be realized based on developments in integration, automation and multiplexing. Finally, the future prospects and remaining challenges of miniaturized biosensors for POC testing are discussed. •To meet the increasing need for POC testing, researchers need to consider biosensor miniaturization.•Miniaturization strategies, including handheld instrument and microfluidic platform-assisted biosensors are highlighted.•Recognitions for miniaturized biosensors and recent advances in integration, multiplexing and automation are described.•Future prospects and remaining challenges of miniaturized biosensors for POC testing are discussed.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2019.115701