Electrochemical sensors targeting salivary biomarkers: A comprehensive review

The analysis of salivary markers has grown into a promising non-invasive route for easy, safe, and pain-free monitoring and has the potential to alter the existing way of clinical diagnosis and management. Advancements in sensing technology, the arrival of novel materials, the innovative fabrication...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2021-02, Vol.135, p.116164, Article 116164
Main Authors: Mani, Veerappan, Beduk, Tutku, Khushaim, Walaa, Ceylan, Ayse Elcin, Timur, Suna, Wolfbeis, Otto S., Salama, Khaled Nabil
Format: Article
Language:English
Subjects:
Biomarker
Biosensor
Cancer
Cardiovascular disease
Clinical diagnostics
Drug abuse
Microfluidics
Saliva
Viral disease
Wearable sensors
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Summary:The analysis of salivary markers has grown into a promising non-invasive route for easy, safe, and pain-free monitoring and has the potential to alter the existing way of clinical diagnosis and management. Advancements in sensing technology, the arrival of novel materials, the innovative fabrication technologies, and sampling accuracy have made significant progress and establishing saliva as a fluid for routine analysis. Salivary biomarkers are useful to diagnose not only cardiovascular diseases, bacterial or viral infections but also cancer, diabetes, or Alzheimer's disease. In addition, saliva is analyzed in toxicology, forensic medicine and drug abuse. Electrochemical assays and sensors are well accepted tools because they allow for fast and cost-effective analysis. Nanomaterials, microfluidics, smartphones, paper-based, flexible and wearable devices have made significant advancements in saliva analysis. This review discusses the recent progress made in electrochemical methodologies for detecting salivary biomarkers. [Display omitted] •Electrochemical (bio) sensors developed over the past 10 years for salivary biomarkers are reviewed.•Substances of salivary glands, external substances, microorganisms, and permeating substances from blood are covered.•Diagnosis of numerous acute, chronic, and infectious diseases are discussed.•Electrochemical sensors for screening clinical drugs and drug abuse are reviewed.•Microfluidics, smartphone technology, and wearable electronics based saliva diagnostics are highlighted.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2020.116164