Microfluidic paper-based chips in rapid detection: Current status, challenges, and perspectives

Microfluidic paper-based chips (μPCs) are micro-laboratory analysis systems that use paper instead of traditional microfluidic substrate materials and miniaturize biochemical reactions. Based on traditional 2D μPCs, the novel μPCs are innovative 3D structure chips that are realized by fluid channel...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2021-10, Vol.143, p.116371, Article 116371
Main Authors: Qin, Xiaoxiao, Liu, Jiajing, Zhang, Zhong, Li, Jinhua, Yuan, Li, Zhang, Zhiyang, Chen, Lingxin
Format: Article
Language:English
Subjects:
Food safety
Microfluidic paper-based chips
Pathogen
Portable device
Rapid detection
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Summary:Microfluidic paper-based chips (μPCs) are micro-laboratory analysis systems that use paper instead of traditional microfluidic substrate materials and miniaturize biochemical reactions. Based on traditional 2D μPCs, the novel μPCs are innovative 3D structure chips that are realized by fluid channel construction, channel microvalve, folding and other fluid control methods. In recent years, μPCs have developed rapidly in terms of design and integration and have been widely used in food safety, environmental residue pollution, pathogen detection and other applications. Due to their advantages of low cost, portability and satisfactory thermal stability, they have unique potential in the field of rapid detection. Herein, based on the detailed preparation, we focus on the selection of the paper substrate, microfluidic chip hydrophilic/hydrophobic processing and substrate modification. We highlight the latest research progress of μPCs in rapid detection from 2014 to 2021, and discuss the remaining challenges and future perspectives for further development. •This paper focuses on the paper substrate selection, microfluidic chip processing, and paper modification.•A systematic summary of various functional materials for the hydrophobic modification of paper chips is presented.•The latest research progress on microfluidic paper-based chips from 2014 to 2021 is summarized.•This review provides a theoretical basis for microfluidic paper-based chips development in the field of rapid detection.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2021.116371