Vacuum ultraviolet photoionization on-line mass spectrometry: Instrumentation developments and applications

On-line mass spectrometry (MS) techniques provide high time resolution for insight into chemical changes, while eliminating the potential artifacts acquired during sample collection and pretreatment. Vacuum ultraviolet photoionization (VUV-PI) is a universal and soft ionization source for MS, the ad...

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Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2022-04, Vol.149, p.116542, Article 116542
Main Authors: Dang, Min, Liu, Ruidong, Dong, Fengshuo, Liu, Bing, Hou, Keyong
Format: Article
Language:English
Subjects:
Chemical ionization
On-line mass spectrometry
Single photon ionization
Vacuum ultraviolet lamp photoionization
Volatile organic compounds
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Summary:On-line mass spectrometry (MS) techniques provide high time resolution for insight into chemical changes, while eliminating the potential artifacts acquired during sample collection and pretreatment. Vacuum ultraviolet photoionization (VUV-PI) is a universal and soft ionization source for MS, the advantages of less fragments, high sensitivity and short response time make it suitable for applications in the field of fast on-line analysis. In this review, we discuss the latest instrumental developments and characterization efforts on VUV-PI-MS, including the modification of the VUV lamp-based ionization source and its sampling interfaces. Different ionization mechanisms with VUV lamp under vacuum and atmospheric pressure are discussed, as well as the influence of dopants for photon driven chemical ionization. Several applications are presented, including the analysis of environmental volatile organic compounds (VOCs), dioxin precursors, explosives, illegal drugs, etc. In conclusion, further developments and improvements in the performance, capabilities, and ease-of-use of VUV-PI-MS may reasonably be anticipated. •Vacuum ultraviolet photoionization mechanisms and its influencing factors were summarily interpreted.•The developments of high-sensitivity ionization sources based on VUV lamp were summarized.•The applications of VUV-PI-MS in various field of fast online analysis were presented.•The directions for further improvement of VUV-PI-MS were proposed.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2022.116542