Dual/Multi-responsive fluorogenic probes for multiple analytes in mitochondria: From design to applications

As the "powerhouse" of the cells, mitochondria participate in numerous energy metabolism processes. Abnormal structure and function of mitochondria will affect the activities of living cell, leading to pathological changes including degenerative diseases, metabolic diseases, genetic diseas...

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Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2022-10, Vol.155, p.116697, Article 116697
Main Authors: Guo, Jiaying, Fang, Bin, Bai, Hua, Wang, Limin, Peng, Bo, Qin, Xu-Jun, Fu, Li, Yao, Chuanhao, Li, Lin, Huang, Wei
Format: Article
Language:English
Subjects:
Bioimaging
Biomarkers
Dual/Multi-responsive
Fluorogenic probes
Mitochondria
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Summary:As the "powerhouse" of the cells, mitochondria participate in numerous energy metabolism processes. Abnormal structure and function of mitochondria will affect the activities of living cell, leading to pathological changes including degenerative diseases, metabolic diseases, genetic diseases, and tumors. Early diagnosis and treatment of mitochondrial diseases are essential to improve the survival rate of patients. Therefore, rapid, sensitive and simultaneous detection of multiple analytes of mitochondrial diseases is of great importance for human health. In recent years, dual/multi-responsive fluorogenic probes (DMRFPs) with specific recognition functions and selective signal readout/conversion for analytes in mitochondria have been developed. In this review, we have summarized the recent advances in DMRFPs for analytes detection in mitochondria such as simultaneous detection of i) microenvironment and related analytes, ii) redox species and iii) other analytes in mitochondria and given a brief perspective on the design of DMRFPs and their applications to inspire the new generation of mitochondrial-targeting DMRFPs. •The review introduced the importance of monitoring analytes and their interrelations in pathophysiological processes.•The review focused on the design strategies and detection mechanisms of DMRFPs.•The performances of biological applications of DMRFPs in diverse pathophysiological models are summarized.•The drawbacks and future perspectives of DMRFPs for multiple analytes in mitochondria are discussed.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2022.116697