Active site rich MXene as a sensing interface for brain neurotransmitter's and pharmaceuticals: One decade, many sensors

• Published in: TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2023-07, Vol.164, p.117096, Article 117096
• Main Authors: Pattan-Siddappa, Ganesh, Ko, Hyun-U, Kim, Sang-Youn
• Format: Article
• Language: English
• Subjects: Analytical performance; Brain neurotransmitter; Electroanalytical methods; MXene; Pharmaceuticals; Sensor
• ISSN: 0165-9936; 1879-3142
• DOI: 10.1016/j.trac.2023.117096

The growing commercial market demand for sensors has sparked the curiosity of researchers in investigating with novel materials to boost electrochemical sensing properties and develop rapid, affordable, real-time, eco-friendly, and sensitive detection devices that could generate valuable data useful for health and environmental surveillance. Due to its surface chemistry and rapid charge transfer rate, the heterostructure of MXene nanocomposites exhibits a vibrant, dynamic, and excellent analytical performance in electrochemical sensing applications. The substantial advances in the synthesis of MXene methods, and the usage of its heterostructure compounds in the fabrication of electrochemical sensors were explored in this review. The MXene synthesis challenges must be overcome, though, in order to provide an easy, safe, environmentally friendly, and greener etching procedure. In the near future, the design of highly sensitive and specific sensing platforms for a variety of applications may soon be made possible by the development of MXene-based electrochemical sensors. •Current state-of-the-art and advancements in MXene synthesis techniques are critically reviewed.•MXenes and their heterostructures applications for sensing brain neurotransmitters and pharmaceuticals are highlighted.•All steps of the electroanalytical methods are critically discussed.•The challenges and future potentials of MXenes synthesis and sensing applications are meticulously summarized.