Blood donors – Serious adverse reactions (SAR) 2010–2014 EFS Châteauroux, France

• Published in: Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 2015-06, Vol.22 (2), p.62-65
• Main Authors: Riga, A., Sapey, T., Bacanu, M., Py, J.-Y., Dehaut, F.
• Format: Article
• Language: English
• Subjects: Adverse reactions; Blood donors; Donation time course; Donneurs de sang; Donor vigilance; Malaise vagal; Mauvaise réaction; Moment du don; Vasovagal syncope; Vigilance donneur
• ISSN: 1246-7820
• DOI: 10.1016/j.tracli.2015.04.002

In 2013, the national French incidence of serious adverse reactions (SAR) was 155.7 per 100,000 donations and 82% of SAR were grade 2 (French classification of SAR related to blood donors) The purpose of our study was to describe the profile of blood donator candidate which had a SAR in our center. The study contains all the SAR superior to grade 1 occurred on the site EFS Châteauroux (site and mobile blood collection) from January 2010 to October 31, 2014. We analyzed 37 parameters from the e-fit files (e-site French blood vigilance) and In-log software. We identified 82 SAR for 72,553 blood donations (incidence: 113.02 SAR per 100,000 donations). Forty-one men and 41 women, middle age 39 years (18–66). Average height: 1.68m (1.49–1.85); average weight: 68kg (50–98); body mass index (kg/m2): 24,13(18.6–31.9). All donors were Caucasian and 30% unemployed. We found 74 vasovagal syncope (VVS), 5 hematomas, 2 arterial injuries and an adverse reaction to citrate. In 90%, the SAR was immediate and of grade 2 in 85% of cases. Thirty-seven percent of SAR were first donation in connection with whole blood in 87% of cases. Regarding the seniority of donors, the number of average donations (whole blood, plasma, platelets) was 16.5. An SAR determined the stop of blood donation in 65% of cases with nearly 80% stoppage if it was a first donation. Seventy-three percent of SAR as a VVS took place during blood collection or within 5minutes following the end of the donation. Sixty-one percent were men. Forty-four percent of cases were a first donation and 83% occurred in mobile blood collection. Average age was 36 years. The result was a permanent stop of all type of donations in 76% of cases. Twenty-seven percent of SAR as a VVS took place beyond 5minutes after the end of the donation. Seventy-five percent were women. Thirty percent of cases were a first donation and 95% of SAR occurred in mobile blood collection. Average age was 42 years. The result was a permanent stop of all type of donations in 40% of cases. When the SAR as a VVS occurs during or within 5minutes following the end of the donation, it leads to a permanent stop of any type of donation in 76% of cases. En 2013, l’incidence nationale était de 155,7 EIGD pour 100 000 dons dont 82 % étaient de grade 2. Le but de notre étude était de décrire le profil du candidat au don du sang ayant eu un EIGD dans notre centre. L’étude contient tous les EIGD supérieurs au grade 1 survenus sur le site de Châteauroux (collect