Antioxidant supplementation may improve renal transplant function: A preliminary report

Dysfunction of the renal graft may not only be due to rejection but also other causes such as ischemia and reperfusion injury and calcineurin inhibitor nephrotoxicity. Antioxidant free radical scavengers may decrease oxidative stress and lipid peroxidation. Previous animal studies suggest that vitam...

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Bibliographic Details
Published in:Transplantation proceedings 2004-10, Vol.36 (8), p.2438-2439
Main Authors: Loong, C.C., Chang, Y.H., Wu, T.H., King, K.L., Yang, W.C., Wu, C.W., Lui, W.Y.
Format: Article
Language:English
Subjects:
Adult
Antioxidants - administration & dosage
Antioxidants - therapeutic use
Ascorbic Acid - therapeutic use
Biological and medical sciences
Creatinine - blood
Dietary Supplements
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Kidney Transplantation - physiology
Male
Medical sciences
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Time Factors
Tissue, organ and graft immunology
Vitamin E - therapeutic use
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Summary:Dysfunction of the renal graft may not only be due to rejection but also other causes such as ischemia and reperfusion injury and calcineurin inhibitor nephrotoxicity. Antioxidant free radical scavengers may decrease oxidative stress and lipid peroxidation. Previous animal studies suggest that vitamins C (ascorbic acid) and E (alpha-tocopherol) are both strong antioxidants, that decrease oxidative stress caused by ischemia-reperfusion injury and calcineurin inhibitor nephrotoxicity. But there have been only limited reports about clinical efficacy. We report five cases supplemented with vitamin C (500 mg per day), vitamin E (500 mg per day), or both. After a 1- to 3-month prescription, the serum creatinine level decreased more than 20% from the original value. Interestingly, one patient had this experience: he ceased vitamin E for 1 month due to noncompliance. The serum creatinine level increased more than 50%. When he took vitamin E again, his serum creatinine level declined and returned to the previous level. From our limited experience, antioxidant supplementation with vitamin C or E may improve renal transplant function, especially in grafts donated from marginal donors.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2004.06.053