Alcohol- and Substance-Dependent Subjects: The Correlated Factors in Qualifying for Liver Transplantation

Abstract Objectives To identify the most significant variables in determining if candidates with past or current addictions can be considered for liver transplantation. Methods Data relating to 58 cases from January 2001 to December 2003 were collected and analyzed. Results The decisional algorithm...

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Bibliographic Details
Published in:Transplantation proceedings 2007-07, Vol.39 (6), p.1861-1863
Main Authors: Gallimberti, L, Forza, G, Angeli, P, Vitale, A, Cillo, U, Gatta, A, D’Amico, D
Format: Article
Language:English
Subjects:
Alcoholism
Algorithms
Biological and medical sciences
Drug addictions
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Liver Transplantation - mortality
Liver Transplantation - statistics & numerical data
Liver, biliary tract, pancreas, portal circulation, spleen
Medical sciences
Patient Selection
Substance-Related Disorders
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Tissue, organ and graft immunology
Toxicology
Treatment Outcome
Waiting Lists
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Summary:Abstract Objectives To identify the most significant variables in determining if candidates with past or current addictions can be considered for liver transplantation. Methods Data relating to 58 cases from January 2001 to December 2003 were collected and analyzed. Results The decisional algorithm identified by discriminant analysis is based on the following variables: the duration of remission, treatment adherence, and the presence of a valid help relationship. Candidates undergoing initial remission (up to 12 months) must demonstrate both adherence and affective support; those with over 5 years of remission, however, are considered sufficiently reliable. A positive judgment is significantly correlated to overall survival and clinical improvement even without transplantation. Conclusions In toxicological evaluation, treatment adherence and the presence of a valid help relationship for patients in remission from addictions can improve the selection criteria for liver transplantation, making it more dependable.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2007.05.024