Correlation of Cancer Development and Human Papilloma Virus Infection in Patients After Organ Transplantation

Immunosuppressed patients are at higher risk of developing human papilloma virus (HPV) cancerous and precancerous lesions in the anogenital region Carcinogenesis after organ transplantation due to immunosuppressive therapy is the major cause of long-term negative transplantation results. This is a r...

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Bibliographic Details
Published in:Transplantation proceedings 2020-09, Vol.52 (7), p.1982-1984
Main Authors: Suwalska, Anna, Smolarczyk, Katarzyna, Kosieradzki, Maciej, Fiedor, Piotr
Format: Article
Language:English
Subjects:
Adult
Anus Neoplasms - epidemiology
Anus Neoplasms - immunology
Anus Neoplasms - virology
Female
Humans
Immunocompromised Host
Immunosuppression - adverse effects
Male
Middle Aged
Organ Transplantation
Papillomavirus Infections - complications
Papillomavirus Infections - epidemiology
Papillomavirus Infections - immunology
Transplant Recipients
Urogenital Neoplasms - epidemiology
Urogenital Neoplasms - immunology
Urogenital Neoplasms - virology
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Summary:Immunosuppressed patients are at higher risk of developing human papilloma virus (HPV) cancerous and precancerous lesions in the anogenital region Carcinogenesis after organ transplantation due to immunosuppressive therapy is the major cause of long-term negative transplantation results. This is a rationale for the improvement of transplantation programs with carcinogenesis risk stratification in patients referred for transplantation. There is a need for a study on HPV-related carcinogenesis also in terms of its risk factors in the population after organ transplantation. This study aimed to assess the morbidity of anogenital carcinoma in patients with HPV infection, including those after organ transplantation and evaluate risk factors for carcinoma occurrence in patients after organ transplantation and with HPV infection. Our analysis directly indicates the group of patients with a high risk of HPV-related oncological complications of immunosuppression in anogenital region. •Carcinogenesis after organ transplantation is the major cause of a long-term negative transplantation result.•HPV infection in transplanted patients is a direct factor in the development of cancer.•Immunosuppressive treatment in patients after transplantation significantly reduces the time of development of the cancer associated with an HPV infection.•It is necessary to implement prophylactic algorithms for an HPV infection in patients after transplantation.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2020.03.032