Immunosuppression in uterine transplantation

Uterine transplantation (UTx) is the only effective treatment for uterine infertility patients to become genetic mothers. After decades of research, the surgical methods of UTx are very developed. There are numerous factors that affect the results of UTx, such as selection of the donor uterus before...

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Bibliographic Details
Published in:Transplant immunology 2020-12, Vol.63, p.101335, Article 101335
Main Authors: Zhang, Rui, Deng, Shou-Long, Lian, Zheng-Xing, Yu, Kun
Format: Article
Language:English
Subjects:
Drug-Related Side Effects and Adverse Reactions
Female
Graft Rejection - drug therapy
Graft Rejection - immunology
Humans
Immunosuppression
Immunosuppressive Agents - therapeutic use
Infertility, Female - therapy
Organ Transplantation
Pregnancy - immunology
Pregnancy Complications
Uterine transplantation
Uterus - transplantation
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Summary:Uterine transplantation (UTx) is the only effective treatment for uterine infertility patients to become genetic mothers. After decades of research, the surgical methods of UTx are very developed. There are numerous factors that affect the results of UTx, such as selection of the donor uterus before transplantation, immunosuppressive therapy post-transplantation, rejection monitoring, and immune tolerance. Studies have shown that immune rejection is a crucial factor affecting the survival rate after organ transplantation. Unlike liver or kidney transplantation, the aim of UTx is to obtain a functional uterus that is able to support successful pregnancy and birth of a healthy fetus. Because of the unique purpose of UTx, its immunosuppressive program is relatively specialized. Some immunosuppressive agents can cause perinatal complications, and inducing immune tolerance is necessary to resolve these side effects. Further understanding of the immune mechanism of UTx and the continuous development of new immunosuppressive agents, combined with the application of assisted reproductive technology, will be more conducive to the realization of UTx to breed offspring.
ISSN:0966-3274
1878-5492
DOI:10.1016/j.trim.2020.101335