Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Outcomes of survival, toxicity, sphincter preserving and prognostic factors

This study aimed to compare preoperative chemoradiotherapy (CRT) with postoperative CRT regarding survival, local control, disease control, sphincter preservation, toxicity and also prognostic factors for the treatment of locally advanced rectal cancer. Records of 140 patients with locally advanced...

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Bibliographic Details
Published in:Transplant immunology 2021-12, Vol.69, p.101489, Article 101489
Main Authors: Duzova, Mursel, Basaran, Hamit, Inan, Gokcen, Gul, Osman Vefa, Eren, Orhan Onder, Korez, Muslu Kazım
Format: Article
Language:English
Subjects:
Chemoradiotherapy
Humans
Locally advanced rectal cancer
Postoperative chemoradiotherapy
Postoperative Period
Preoperative chemoradiotherapy
Prognosis
Prognostic factors
Rectal Neoplasms - drug therapy
Retrospective Studies
Survival
Toxicity
Treatment Outcome
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Summary:This study aimed to compare preoperative chemoradiotherapy (CRT) with postoperative CRT regarding survival, local control, disease control, sphincter preservation, toxicity and also prognostic factors for the treatment of locally advanced rectal cancer. Records of 140 patients with locally advanced rectal cancer who received preoperative or postoperative CRT were analyzed retrospectively. We compared the treatment groups (preoperative vs postoperative) according to baseline characteristics (demographic and rectal cancer disease characteristics), and also carried out the survival analyses. From January 2010 to December 2019, 140 patients were included in the analysis, 65 received preoperative treatment and 75 postoperative treatment. There was no difference in survival, recurrence or distant metastasis rate in both treatment groups. The ratios of the failure to complete adjuvant chemotherapy (32% vs 4.6%) and acute grade 3–4 toxicity (32% vs 6.2%) were higher in the postoperative group (p 
ISSN:0966-3274
1878-5492
DOI:10.1016/j.trim.2021.101489