Wegener's granulomatosis: The current understanding

Wegener's granulomatosis (WG) is a rare systemic disease characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. It occurs as a limited form or generalized form and usually presents with nonspecific symptoms in its ear...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2005-09, Vol.100 (3), p.265-270
Main Authors: Ponniah, I., Shaheen, Ahmed, Shankar, K.A., Kumaran, M.G.
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - therapeutic use
Antibodies, Antineutrophil Cytoplasmic - blood
Biological and medical sciences
Cyclophosphamide - therapeutic use
Dental Care for Chronically Ill
Gingivitis - diagnosis
Gingivitis - etiology
Granulomatosis with Polyangiitis - blood
Granulomatosis with Polyangiitis - complications
Granulomatosis with Polyangiitis - diagnosis
Granulomatosis with Polyangiitis - drug therapy
Humans
Immunosuppressive Agents - therapeutic use
Medical sciences
Oral Ulcer - etiology
Otorhinolaryngology. Stomatology
Prednisone - therapeutic use
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Secondary Prevention
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Summary:Wegener's granulomatosis (WG) is a rare systemic disease characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. It occurs as a limited form or generalized form and usually presents with nonspecific symptoms in its early stages, making the diagnosis of this disease more elusive. Strawberry gingivitis is the most common oral manifestation and is characteristic. Prompt recognition of this early manifestation is of utmost importance for the institution of early treatment, thereby avoiding serious complications. The present paper selectively reviews the literature regarding the current status of WG with respect to diagnosis, laboratory features, and treatment.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2005.04.018