Anesthetic efficacy and pain induced by dental anesthesia: the influence of gender and menstrual cycle

Objective To assess the influence of the menstrual cycle and oral contraceptives on pain sensitivity and local anesthetic effectiveness. Study design Thirty volunteers were designated into 3 groups (n = 10): group 1, women using contraceptives; group 2, women not using contraceptives; and group 3, m...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2007-02, Vol.103 (2), p.e34-e38
Main Authors: Tófoli, Giovana Radomille, DDS, MSc, Ramacciato, Juliana Cama, DDS, MSc, ScD, Volpato, Maria Cristina, DDS, MSc, ScD, Meechan, Jonh G., PhD, DDS, Ranali, José, DDS, MSc, ScD, Groppo, Francisco Carlos, DDS, MSc, ScD
Format: Article
Language:English
Subjects:
Administration, Buccal
Adult
Anesthesia, Dental - adverse effects
Anesthesia, Dental - methods
Anesthetics, Local - administration & dosage
Anesthetics, Local - adverse effects
Contraceptives, Oral
Dental Pulp - drug effects
Dental Pulp Test
Double-Blind Method
Epinephrine - administration & dosage
Facial Pain - etiology
Facial Pain - prevention & control
Female
Humans
Injections - adverse effects
Lidocaine - administration & dosage
Lidocaine - adverse effects
Male
Menstrual Cycle - physiology
Pain Threshold
Reaction Time
Sex Factors
Surgery
Vasoconstrictor Agents - administration & dosage
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Summary:Objective To assess the influence of the menstrual cycle and oral contraceptives on pain sensitivity and local anesthetic effectiveness. Study design Thirty volunteers were designated into 3 groups (n = 10): group 1, women using contraceptives; group 2, women not using contraceptives; and group 3, men. Groups 1 and 2 had a buccal infiltration of 2% lidocaine with 1:100,000 epinephrine at the upper-right canine during each one of the 5 phases of the menstrual cycle and group 3 at a randomly selected day. Pain threshold, latency period, and pulpal anesthesia were measured with an electrical pulp tester. Injection discomfort was recorded. Data were analyzed with Friedman and Kruskal-Wallis tests. Results Pain threshold was higher in men; however, there were no significant differences ( P > .05) in anesthetic duration and injection discomfort. Conclusion Injection discomfort and clinical effectiveness of local anesthetics are not related to sex, phases of the menstrual cycle, or use of oral contraceptives.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2006.08.024