Treatment results of continuous intra-arterial CBDCA infusion chemotherapy in combination with radiation therapy for locally advanced tongue cancer

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2008-06, Vol.105 (6), p.714-719
• Main Authors: Fuwa, Nobukazu, MD, Kodaira, Takeshi, MD, Furutani, Kazuhisa, MD, Tachibana, Hiroyuki, MD, Nakamura, Tatsuya, MD
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Carboplatin - administration & dosage; Carboplatin - toxicity; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Carotid Artery, External; Drug Administration Schedule; Female; Fluorouracil - administration & dosage; Fluorouracil - toxicity; Humans; Infusions, Intra-Arterial; Injections, Intravenous; Kaplan-Meier Estimate; Male; Medical sciences; Middle Aged; Neoplasm Staging; Organoplatinum Compounds - administration & dosage; Organoplatinum Compounds - toxicity; Otorhinolaryngology. Stomatology; Radiotherapy Dosage; Radiotherapy, Adjuvant; Retrospective Studies; Surgery; Tongue - blood supply; Tongue Neoplasms - drug therapy; Tongue Neoplasms - pathology; Tongue Neoplasms - radiotherapy; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1016/j.tripleo.2007.11.023

Objective The objective of this study was to improve the treatment results for locally advanced tongue cancer. A combination of radiotherapy with continuous intra-arterial therapy using CBDCA was used. Study design According to TNM staging (1997), 29 patients had stage III lesions and 11 patients had stage IV (M0) lesions. A catheter was inserted through the lingual artery in 26 patients, through the external carotid artery in 11 patients, and through the faciolingual trunk in 2 patients. CBDCA was continuously infused for 4 to 6 weeks. With IA chemotherapy, external irradiation (median dose: 46.8 Gy) was simultaneously performed, and 1 to 2 courses of systemic chemotherapy were performed in 19 patients before intra-arterial chemotherapy. Results The 5-year local control rate was 65%. The 5-year OS rate was 39.5%. There were no clinically significant adverse side effects. Conclusion Continuous IA CBDCA and concurrent radiation therapy can be delivered safely with good efficacy for locally advanced carcinoma of the tongue.