Preparation of vancomycin-loaded alginate hydrogel coating on magnesium alloy with enhanced anticorrosion and antibacterial properties

•A vancomycin-loaded sodium alginate hydrogel coating was prepared on Mg alloy (MgA).•The corrosion resistance of the modified MgA was significantly increased.•The modified MgA exhibited excellent antibacterial property and hemocompatibility. In this study, vancomycin (Van)-loaded sodium alginate (S...

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Bibliographic Details
Published in:Thin solid films 2020-01, Vol.693, p.137679, Article 137679
Main Authors: Du, Minting, Huang, Linlin, Peng, Mengke, Hu, Fenyan, Gao, Qiang, Chen, Yashao, Liu, Peng
Format: Article
Language:English
Subjects:
Antibacterial property
Anticorrosion
Glycopeptide antibiotic
Hemocompatibility
Hydrogel coating
Magnesium alloy
Surface modification
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Summary:•A vancomycin-loaded sodium alginate hydrogel coating was prepared on Mg alloy (MgA).•The corrosion resistance of the modified MgA was significantly increased.•The modified MgA exhibited excellent antibacterial property and hemocompatibility. In this study, vancomycin (Van)-loaded sodium alginate (SA) hydrogel coating was fabricated on micro-arc oxidation (MAO)-treated magnesium alloy (MgA) surface via the electrostatic interaction between polyethyleneimine and SA to enhance anticorrosion, hemocompatibility, and antibacterial properties of MgA substrate. The surface morphology and chemical composition of the modified MgA substrate were characterized by scanning electron microscopy and X-ray photoelectron spectroscopy. The results showed the successful preparation of Van-loaded SA hydrogel coating on MgA/MAO substrate. Furthermore, the anticorrosion property of the coated MgA in simulated body fluids was also evaluated. The potentiodynamic polarization test indicated that corrosion resistance of MgA coated with the Van-loaded SA hydrogel was significantly improved. Biocompatibility of the modified MgA substrates was investigated by in vitro platelets adhesion assay, hemolysis ratio test, and dynamic coagulation time test. The results indicated that the modified MgA exhibited excellent antibacterial property and hemocompatibility. This study may provide an alternative pathway for surface modification of MgA implants to enhance their corrosion resistance and biocompatibility.
ISSN:0040-6090
DOI:10.1016/j.tsf.2019.137679