Oogenesis and embryogenesis inhibition induced by two new ethyl-carbamates in the cattle tick Rhipicephalus microplus

The purpose of this work was to contribute to the understanding of the mechanism of action of two new ixodicides. The histological and ultrastructural alterations of Rhipicephalus microplus oocytes (San Alfonso strain) treated with two new ethyl-carbamates (ethyl-4-bromophenyl carbamate and ethyl-4-...

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Published in:Ticks and tick-borne diseases 2020-03, Vol.11 (2), p.101326, Article 101326
Main Authors: Iturbe-Requena, Sandra L., Prado-Ochoa, María G., Velázquez-Sánchez, Ana M., García-Hernández, Fernando, Cossío-Bayúgar, Raquel, Muñoz-Guzmán, Marco A., Ángeles, Enrique, Alba-Hurtado, Fernando
Format: Article
Language:English
Subjects:
Acaricides
Animals
Carbamates
Embryo, Nonmammalian - drug effects
Embryogenesis
Embryonic Development - drug effects
Microscopy
Microscopy, Electron, Transmission
Microscopy, Fluorescence
Oocytes
Oogenesis
Oogenesis - drug effects
Ovum - drug effects
Rhipicephalus - embryology
Rhipicephalus - growth & development
Rhipicephalus microplus
TEM
Tick Control
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Summary:The purpose of this work was to contribute to the understanding of the mechanism of action of two new ixodicides. The histological and ultrastructural alterations of Rhipicephalus microplus oocytes (San Alfonso strain) treated with two new ethyl-carbamates (ethyl-4-bromophenyl carbamate and ethyl-4-chlorophenyl carbamate) by the adult immersion test were evaluated by light microscopy and transmission electron microscopy. The effects of the carbamates on embryogenesis in eggs were evaluated by fluorescence microscopy using DAPI staining. Both ethyl-carbamates inhibited the maturation of most oocytes and induced a concentration-dependent decrease (r2  = 0.5, p 
ISSN:1877-959X
1877-9603
DOI:10.1016/j.ttbdis.2019.101326