Pulmonary oedema as a suspected adverse drug reaction following vincristine administration to a cat: A case report

This report describes recurrent respiratory distress following vincristine administration to a cat with chronic lymphocytic leukaemia. The cat was treated with a combination of vincristine, chlorambucil and prednisolone with initial success. After approximately 4 months, dyspnoea developed within 6...

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Bibliographic Details
Published in:The veterinary journal (1997) 2008-07, Vol.177 (1), p.130-133
Main Authors: Polton, Gerry A., Elwood, Clive M.
Format: Article
Language:English
Subjects:
Adverse effect
adverse effects
Animals
antineoplastic agents
Antineoplastic Agents, Phytogenic - adverse effects
Antineoplastic Agents, Phytogenic - therapeutic use
case studies
Cat Diseases - chemically induced
Cat Diseases - drug therapy
Cats
Chemotherapy
chlorambucil
combination drug therapy
disease course
dyspnea
Dyspnoea
edema
etiology
Feline
Female
first aid
Leukemia, Lymphoid - drug therapy
Leukemia, Lymphoid - veterinary
lungs
lymphocytic leukemia
Non-cardiogenic pulmonary oedema
prednisolone
Pulmonary Edema - chemically induced
Pulmonary Edema - veterinary
respiratory tract diseases
signs and symptoms (animals and humans)
veterinary drugs
vincristine
Vincristine - adverse effects
Vincristine - therapeutic use
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Summary:This report describes recurrent respiratory distress following vincristine administration to a cat with chronic lymphocytic leukaemia. The cat was treated with a combination of vincristine, chlorambucil and prednisolone with initial success. After approximately 4 months, dyspnoea developed within 6 h of vincristine administration. Emergency therapy was instituted resulting in a full recovery. Further vincristine was administered; dyspnoea was similarly noted after all but one of these treatments. Dyspnoeic episodes were not attributable to alterations in vincristine dose or method of administration. The repeated temporal association was consistent with a suspected adverse drug reaction to vincristine.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2007.04.015