Pharmacokinetics of enrofloxacin and flunixin meglumine and interactions between both drugs after intravenous co-administration in healthy and endotoxaemic rabbits

The purpose of this study was to determine the pharmacokinetics and possible interactions of enrofloxacin (ENR) and flunixin meglumine (FM) in healthy rabbits and in rabbits where endotoxaemia had been induced by administering Escherichia coli lipopolysaccharide (LPS). Six male adult New Zealand Whi...

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Bibliographic Details
Published in:The veterinary journal (1997) 2008-09, Vol.177 (3), p.418-424
Main Authors: Elmas, Muammer, Yazar, Enver, Uney, Kamil, Er (Karabacak), Ayşe, Traş, Bünyamin
Format: Article
Language:English
Subjects:
adverse effects
Animals
Anti-Inflammatory Agents, Non-Steroidal - blood
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Area Under Curve
Blood Chemical Analysis - veterinary
blood chemistry
Clonixin - analogs & derivatives
Clonixin - blood
Clonixin - pharmacokinetics
Cross-Over Studies
Drug Interactions
Endotoxaemia
endotoxemia
Endotoxemia - blood
Endotoxemia - drug therapy
Endotoxemia - veterinary
Enrofloxacin
Escherichia coli
flunixin
Flunixin meglumine
Fluoroquinolones - blood
Fluoroquinolones - pharmacokinetics
Half-Life
Injections, Intravenous - veterinary
intravenous injection
lipopolysaccharides
Lipopolysaccharides - toxicity
Male
Pharmacokinetics
Rabbits
Rabbits - metabolism
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Summary:The purpose of this study was to determine the pharmacokinetics and possible interactions of enrofloxacin (ENR) and flunixin meglumine (FM) in healthy rabbits and in rabbits where endotoxaemia had been induced by administering Escherichia coli lipopolysaccharide (LPS). Six male adult New Zealand White rabbits were used for the study. In Phase I, FM (2.2 mg/kg) and ENR (5 mg/kg) were given simultaneously as a bolus intravenous (IV) injection to each healthy rabbit. After a washout period, Phase II consisted of purified LPS administered as an IV bolus injection, then FM and ENR. LPS produced statistically significant increases in some serum biochemical concentrations. After the drugs were co-administered, the kinetic parameters of FM were not significantly different in healthy compared to endotoxaemic rabbits. It is concluded that ENR and FM could be co-administered to rabbits to treat endotoxaemia as no negative interaction was observed between the pharmacokinetics of both drugs.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2007.05.021