Sonochemical synthesis of bismuth(III) oxide decorated reduced graphene oxide nanocomposite for detection of hormone (epinephrine) in human and rat serum

Herein, we report an efficient electrochemical sensor strategy for determination of epinephrine based on Bi2O3 nanoparticle decorated reduced graphene oxide nanocomposite (Bi2O3@RGO). The Bi2O3@RGO was prepared by simple ultrasonic method and then it’s morphological and crystal structure aspects wer...

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Bibliographic Details
Published in:Ultrasonics sonochemistry 2019-03, Vol.51, p.103-110
Main Authors: Manavalan, Shaktivel, Rajaji, Umamaheswari, Chen, Shen-Ming, Govindasamy, Mani, Selvin, S. Steplin Paul, Chen, Tse-Wei, Ali, M. Ajmal, Al-Hemaid, Fahad M.A., Elshikh, M.S.
Format: Article
Language:English
Subjects:
Adrenaline
Animals
Bismuth - chemistry
Blood Chemical Analysis - methods
Chemistry Techniques, Synthetic
Electrocatalyst
Electrodes
Epinephrine - blood
Graphite - chemistry
Hormones - blood
Humans
Metal oxide nanoparticle
Nanostructures - chemistry
Neurotransmitter
Oxidation-Reduction
Rats
Reduced graphene oxide
Ultrasonic Waves
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Summary:Herein, we report an efficient electrochemical sensor strategy for determination of epinephrine based on Bi2O3 nanoparticle decorated reduced graphene oxide nanocomposite (Bi2O3@RGO). The Bi2O3@RGO was prepared by simple ultrasonic method and then it’s morphological and crystal structure aspects were well characterized by physiological instruments. The electrode-electrolyte interfacial properties were examined to ensure the catalytic ability of composite sensing towards EP. The composite was deposited on the multi-conventional screen-printed electrode and was found to be desirable performance toward EP oxidation. The amperometric EP sensing exhibited good reproducible and sensitive which able to detect as low as concentration of 2.14 nM. Furthermore, good reproducibility, long-term stability and repeatability were obtained from the electrode in experiment. Moreover, the EP sensing method was successfully applied in human and rat blood serum, the recoveries were validated by HPLC method. It indicates the reliability of the method in practical analysis.
ISSN:1350-4177
1873-2828
DOI:10.1016/j.ultsonch.2018.10.008