Antibodies Against Botulinum Neurotoxin Type A as a Cause of Treatment Failure After the First Detrusor Injection

Botulinum neurotoxins are increasingly used in treatment for hyperactive detrusor and sphincter function. Although reported results are promising, conditions in some patients are refractory. We report what we believe to be the first urologic case of therapy failure possibly induced by botulinum toxi...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2007-03, Vol.69 (3), p.575.e13-575.e15
Main Authors: Schulte-Baukloh, Heinrich, Bigalke, Hans, Heine, Gert, Pape, Daniela, Stuerzebecher, Burkard, Miller, Kurt, Knispel, Helmut H
Format: Article
Language:English
Subjects:
Administration, Intravesical
Aged
Antibodies - analysis
Botulinum Toxins, Type A - administration & dosage
Botulinum Toxins, Type A - immunology
Humans
Male
Neuromuscular Agents - administration & dosage
Neuromuscular Agents - immunology
Neurotoxins - administration & dosage
Neurotoxins - immunology
Treatment Failure
Urination Disorders - drug therapy
Urination Disorders - physiopathology
Urodynamics
Urology
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Summary:Botulinum neurotoxins are increasingly used in treatment for hyperactive detrusor and sphincter function. Although reported results are promising, conditions in some patients are refractory. We report what we believe to be the first urologic case of therapy failure possibly induced by botulinum toxin antibodies after just one injection and discuss treatment alternatives based on experience in other fields.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2007.01.030