VALUE OF B7-H3 EXPRESSION AS A PREDICTOR OF RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN UROTHELIAL CELL CARCINOMA OF BLADDER

B7-H3 is overexpressed in urothelial carcinoma of the bladder (UCB) and has been shown to be a marker of response to adjuvant chemotherapy post radical cystectomy (RC). Herein, we evaluated the correlation of B7-H3 expression from;transurethral resection of bladder tumor (TURBT) specimens;with patho...

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Published in:Urologic oncology 2024-03, Vol.42, p.S30-S31
Main Authors: Nabavizadeh, Reza, Pessoa, Rodrigo Rodrigues, Dumbrava, Mihai, Horjeti, Edlira, Mahmoud, Ahmed M, Mueller, Brenda, Thapa, Prabin, Boorjian, Stephen A, Cheville, John, Dong, Haidong, Frank, Igor, Lucien, Fabrice
Format: Article
Language:English
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Summary:B7-H3 is overexpressed in urothelial carcinoma of the bladder (UCB) and has been shown to be a marker of response to adjuvant chemotherapy post radical cystectomy (RC). Herein, we evaluated the correlation of B7-H3 expression from;transurethral resection of bladder tumor (TURBT) specimens;with pathological response to neoadjuvant chemotherapy (NAC). Patients treated with NAC prior to RC for UCB between 2003-2021 were identified. B7-H3 expression level in the TURBT specimens was scored between 0 to 300 using H-scoring system. Expression levels of
ISSN:1078-1439
1873-2496
DOI:10.1016/j.urolonc.2024.01.109