Experimental challenge models for Johne's disease: A review and proposed international guidelines

An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide....

Full description

Saved in:
Bibliographic Details
Published in:Veterinary microbiology 2007-06, Vol.122 (3), p.197-222
Main Authors: Hines, Murray E., Stabel, Judith R., Sweeney, Raymond W., Griffin, Frank, Talaat, Adel M., Bakker, Douwe, Benedictus, Geart, Davis, William C., de Lisle, Geoffrey W., Gardner, Ian A., Juste, Ramon A., Kapur, Vivek, Koets, Ad, McNair, Jim, Pruitt, Greg, Whitlock, Robert H.
Format: Article
Language:English
Subjects:
animal age
animal diseases
Animal models
Animals
Biological and medical sciences
Cattle
Cervidae
Challenge
Disease Models, Animal
dosage
drug evaluation
experimental design
Experimental infection
Fundamental and applied biological sciences. Psychology
Goats
guidelines
inoculation methods
international policy and programs
Johne's disease
literature reviews
livestock
Mice
Microbiology
Mycobacterium avium subsp. paratuberculosis
Mycobacterium avium subsp. paratuberculosis - immunology
Mycobacterium avium subsp. paratuberculosis - pathogenicity
Paratuberculosis
Paratuberculosis - prevention & control
Practice Guidelines as Topic
quality control
Sheep
Species Specificity
strains
vaccination
Vaccination - veterinary
vaccines
wildlife diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a “best fit” JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host–pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2007.03.009