Endothelial progenitor cells accelerate the resolution of deep vein thrombosis

Abstract Deep vein thrombosis (DVT) causes high morbidity and mortality. Successful resolution of DVT-related thrombi is the key point in the treatment of DVT. Recently, endothelial progenitor cells (EPCs) which are multipotent progenitor cells mainly residing in human bone marrow have emerged as a...

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Bibliographic Details
Published in:Vascular pharmacology 2016-08, Vol.83, p.10-16
Main Authors: Li, Wen-Dong, Li, Xiao-Qiang
Format: Article
Language:English
Subjects:
Animals
Cardiovascular
Cell Movement
Cell Proliferation
Endothelial progenitor cells
Endothelial Progenitor Cells - metabolism
Endothelial Progenitor Cells - pathology
Endothelial Progenitor Cells - transplantation
Endothelium, Vascular - metabolism
Endothelium, Vascular - pathology
Endothelium, Vascular - physiopathology
Humans
Paracrine Communication
Regeneration
Revascularization
Signal Transduction
Thrombosis
Vascular Remodeling
Venous Thrombosis - metabolism
Venous Thrombosis - pathology
Venous Thrombosis - physiopathology
Venous Thrombosis - surgery
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Summary:Abstract Deep vein thrombosis (DVT) causes high morbidity and mortality. Successful resolution of DVT-related thrombi is the key point in the treatment of DVT. Recently, endothelial progenitor cells (EPCs) which are multipotent progenitor cells mainly residing in human bone marrow have emerged as a promising therapeutic choice for DVT-related thrombus resolution. In this review, we discussed the mobilization and homing property of EPCs into the sites of thrombosis, mechanisms of EPCs in DVT-related thrombus resolution from the aspects of promoting endothelial regeneration, revascularization, vasoactive and angiogenic factor secretion, proteinase generation, thrombus propagation and recurrence prevention, and vein wall remodeling. In addition, we also provide suggestions on EPCs as a therapeutic choice for thrombus resolution.
ISSN:1537-1891
1879-3649
DOI:10.1016/j.vph.2015.07.007