Study on ``liver-soothing and mind-regulating'' acupuncture manipulation in regulating the blood-oxygen concentration in cerebral cortex of PTSD rats

• Published in: World journal of acupuncture-moxibustion 2018-09, Vol.28 (3), p.198-203
• Main Authors: ZHANG, Yan-feng, HAN, Ya-di, ZHAO, Zhong-ting, YAN, Xing-ke
• Format: Article
• Language: English
• Subjects: Blood-oxygen concentration; fNIRs; Liver-soothing and mind-regulating'' acupuncture manipulation; PTSD
• ISSN: 1003-5257
• DOI: 10.1016/j.wjam.2018.09.010

To explore the brain function mechanism of "liver-soothing and mind-regulating" acupuncture manipulation in intervening post-traumatic stress disorder (PTSD). According to random number table method, 60 SD rats were randomly divided into blank group, model group, grabbing group, paroxetine group and acupuncture group. Except for the blank group, all the rats were established into PTSD models through electric shock and incarceration, with model replication for 7 days in total. The rats were given gavage, acupuncture intervention and grabbing fixation 1 h before modeling, with 6 days as 1 course of treatment. Grabbing treatment was performed for 2 courses, with 12 days in total. After modeling, functional near-infrared spectroscopy (fNIRS) system was adopted to collect and record the changes of concentration of Oxy-Hb, Deoxy-Hb and Total-Hb during 3 min in related brain regions of rats in each group after treatment for 5 consecutive days, and the brain function was evaluated. According to the comparison of the time series of blood-oxygen concentration, there were significant differences between model group and blank group as well as grabbing group and blank group (P