Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species

BMS-A is an inhibitor of cholesteryl ester transfer protein and is a highly lipophilic compound (clogP 10.5) with poor aqueous solubility (

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2018-05, Vol.107 (5), p.1352-1360
Main Authors: Chen, Xue-Qing, Ziemba, Theresa, Huang, Christine, Chang, Ming, Xu, Carrie, Qiao, Jennifer X., Wang, Tammy C., Finlay, Heather J., Salvati, Mark E., Adam, Leonard P., Gudmundsson, Olafur, Hageman, Michael J.
Format: Article
Language:English
Subjects:
absorption
Administration, Oral
Animals
Benzamides - administration & dosage
Benzamides - adverse effects
Benzamides - pharmacokinetics
bioavailability
Biological Availability
Cholesterol Ester Transfer Proteins - antagonists & inhibitors
Dogs
Drug Compounding
Drug Stability
Emulsions - chemistry
Excipients - chemistry
Fluorobenzenes - administration & dosage
Fluorobenzenes - adverse effects
Fluorobenzenes - pharmacokinetics
lipid-based formulations
Lipids - chemistry
Macaca fascicularis
Male
Mice, Inbred BALB C
Olive Oil - chemistry
preclinical species
self-emulsifying
Solubility
Triglycerides - chemistry
Water - chemistry
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Description
Summary:BMS-A is an inhibitor of cholesteryl ester transfer protein and is a highly lipophilic compound (clogP 10.5) with poor aqueous solubility (
ISSN:0022-3549
1520-6017
DOI:10.1016/j.xphs.2018.01.003