Cyrene™ as an Alternative Sustainable Solvent for the Preparation of Poly(lactic-co-glycolic acid) Nanoparticles

Toxic and environmental harmful organic solvents are widely applied to prepare poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NP) in standard preparation methods. Alternative non-toxic solvents suffer from disadvantages like high viscosity and plasticizing effects. To overcome these hurdl...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2021-02, Vol.110 (2), p.959-964
Main Authors: Grune, Christian, Thamm, Jana, Werz, Oliver, Fischer, Dagmar
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradable polymer
Differential scanning calorimetry (DSC)
Drug delivery system
Light scattering (dynamic)
Nanomedicine
Nanoparticles
Poly(lactic-co-glycolic acid) (PLGA)
Poorly water-soluble drug
Solvent evaporation
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Summary:Toxic and environmental harmful organic solvents are widely applied to prepare poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NP) in standard preparation methods. Alternative non-toxic solvents suffer from disadvantages like high viscosity and plasticizing effects. To overcome these hurdles, Cyrene™ as a new sustainable, non-toxic and low viscous solvent was used to formulate PLGA NPs. A new preparation method was developed and optimized. Small sized blank NPs around 220 nm with a narrow size distribution and highly negative charge (
ISSN:0022-3549
1520-6017
DOI:10.1016/j.xphs.2020.11.031