Novel effect of Arthrocen (avocado/soy unsaponifiables) on pentylenetetrazole-induced seizure threshold in mice: Role of GABAergic pathway

Arthrocen, an avocado/soy unsaponifiable (ASU)-containing agent, is now used in the clinic and has potentially to decrease joint inflammation and pain associated with mild to severe osteoarthritis. Phytosterols are the major component of Arthrocen with documented anti-inflammatory properties, antiox...

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Bibliographic Details
Published in:Epilepsy & behavior 2020-03, Vol.104 (Pt A), p.106500, Article 106500
Main Authors: Goudarzi, Ramin, Zamanian, Golnaz, Partoazar, Alireza, Dehpour, Ahmadreza
Format: Article
Language:English
Subjects:
(NMDA) receptor
Animals
Anticonvulsants - isolation & purification
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Arthrocen
Dose-Response Relationship, Drug
GABA-A receptor
GABAergic Neurons - drug effects
GABAergic Neurons - physiology
Glycine max
Male
Mice
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - metabolism
Nitric oxide synthase inhibitors
Nitric Oxide Synthase Type II - antagonists & inhibitors
Nitric Oxide Synthase Type II - metabolism
Pentylenetetrazole
Pentylenetetrazole - toxicity
Persea - metabolism
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate - metabolism
Seizure threshold
Seizures - chemically induced
Seizures - drug therapy
Seizures - metabolism
Signal Transduction - drug effects
Signal Transduction - physiology
Treatment Outcome
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Summary:Arthrocen, an avocado/soy unsaponifiable (ASU)-containing agent, is now used in the clinic and has potentially to decrease joint inflammation and pain associated with mild to severe osteoarthritis. Phytosterols are the major component of Arthrocen with documented anti-inflammatory properties, antioxidant, and analgesic effects. Here, we evaluated ASU anticonvulsant effect by its oral administration in pentylenetetrazole (PTZ)-induced seizure threshold and Maximal Electroshock Seizure (MES) Models. Also, the involvement of N-methyl-d-aspartate (NMDA) receptor, benzodiazepine receptor, and nitric oxide (NO) pathway were studied in anticonvulsant effect of ASU in male NMRI mice. Acute administration of Arthrocen (150, 75, 30, 10 mg/kg) by oral gavage significantly (p 
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2019.106500