The effect of experimentally induced chronic hyperglycaemia on serum and pancreatic insulin, pancreatic islet IGF-I and plasma and urinary ketones in the domestic cat ( Felis felis )

Highlights • Diabetes mellitus is on the rise in domestic cats and resembles T2D in humans. • We experimentally induced insulin suppression in serum and β-cells of healthy cats. • We observed plasma and urinary ketones related to the induced insulin suppression. • We for the first time localize IGF-...

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Bibliographic Details
Published in:General and comparative endocrinology 2013-07, Vol.188, p.269-281
Main Authors: Link, Karl R.J, Allio, Ileana, Rand, Jacqueline S, Eppler, Elisabeth
Format: Article
Language:English
Subjects:
adults
Animals
blood glucose
blood serum
Cats
Diabetes
Endocrinology & Metabolism
Feline
Felis
Glucagon
glucose
Glucose toxicity
humans
hyperglycemia
Hyperglycemia - blood
Hyperglycemia - metabolism
hyperlipidemia
IGF-I
Insulin
Insulin - blood
Insulin - metabolism
insulin secretion
insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
Insulin-Secreting Cells - metabolism
islets of Langerhans
Islets of Langerhans - metabolism
ketones
Ketones - blood
Ketones - urine
ketonuria
ketosis
noninsulin-dependent diabetes mellitus
protective effect
therapeutics
toxicity
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Summary:Highlights • Diabetes mellitus is on the rise in domestic cats and resembles T2D in humans. • We experimentally induced insulin suppression in serum and β-cells of healthy cats. • We observed plasma and urinary ketones related to the induced insulin suppression. • We for the first time localize IGF-I in distinct feline islet cells of Langerhans. • We propose a protective effect of IGF-I within the β-cells against hyperglycaemia.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2013.04.029