LncRNA HSPC324 plays role in lung development and tumorigenesis

Lung cancer is a leading cause of cancer-related death in the world. Therefore, identifying the genes and molecular pathways involved in lung development and tumorigenesis can help us improve the therapeutic strategies of lung cancer. Accumulating evidence confirms that long noncoding RNAs, as a nov...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2020-05, Vol.112 (3), p.2615-2622
Main Authors: Jafarzadeh, Meisam, Tavallaie, Mahmood, Soltani, Bahram M., Hajipoor, Sara, Hosseini, Sayed Mostafa
Format: Article
Language:English
Subjects:
Apoptosis
Cancer
Carcinogenesis - genetics
Cell Cycle
Cell Proliferation
Epithelial-Mesenchymal Transition
HSPC324
Humans
LncRNA
Lung - growth & development
Lung - metabolism
Lung adenocarcinoma
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Reactive Oxygen Species - metabolism
RNA, Long Noncoding - physiology
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Summary:Lung cancer is a leading cause of cancer-related death in the world. Therefore, identifying the genes and molecular pathways involved in lung development and tumorigenesis can help us improve the therapeutic strategies of lung cancer. Accumulating evidence confirms that long noncoding RNAs, as a novel layer of regulatory RNA molecules, play an important role in various aspects of the cells. Here, using available high throughput gene expression data, we identified an lncRNA (HSPC324) with high expression level in lung tissue that is distinctly expressed in lung tumor tissues relative to normal. Using GO enrichment and KEGG pathway analyses, we further analyzed the functions and pathways involving the HSPC324-correlated genes. Ectopic expression of lncRNA HSPC324 significantly inhibited proliferation, cell cycle and migration; on the other hand, increased apoptosis and ROS production in lung adenocarcinoma cells. Overall, this study introduces HSPC324 as a new player in the development of lung cancer. •LncRNA HSPC324 is a distinctly expressed gene that differentially expresses between lung cancer and lung tissues•Lung cancerous cells' phenotype is affected by lncRNA HSPC324•LncRNA HSPC324 expression alteration affects EMT process
ISSN:0888-7543
1089-8646
DOI:10.1016/j.ygeno.2020.02.012