Struma Ovarii with a focus of papillary thyroid cancer: a case report and review of the literature

Background. Malignant Struma Ovarii is a rare ovarian neoplasm that is usually asymptomatic and infrequently diagnosed preoperatively. A few case studies have described associated thyrotoxicosis. Case. A 46-year-old female presented for her annual gynecologic exam during which a pelvic mass was appr...

Full description

Saved in:
Bibliographic Details
Published in:Gynecologic oncology 2004-09, Vol.94 (3), p.835-839
Main Authors: Makani, Samina, Kim, Wooshin, Gaba, Arthur R.
Format: Article
Language:English
Subjects:
Carcinoma, Papillary - pathology
Carcinoma, Papillary - surgery
Female
Humans
Literature
Middle Aged
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Papillary thyroid cancer
Struma Ovarii
Struma Ovarii - pathology
Struma Ovarii - surgery
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Malignant Struma Ovarii is a rare ovarian neoplasm that is usually asymptomatic and infrequently diagnosed preoperatively. A few case studies have described associated thyrotoxicosis. Case. A 46-year-old female presented for her annual gynecologic exam during which a pelvic mass was appreciated on physical examination. Patient was asymptomatic at presentation. A follow-up ultrasound confirmed the presence of a 16-cm mass in the right adnexa. Patient underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Histopathology revealed a mature cystic teratoma with features of Struma Ovarii, containing a single 5-mm focus of papillary cancer within the thyroid tissue. Patient subsequently had a thyroid scan that was normal with normal thyroid function. There was no evidence of metastasis. Conclusion. Malignant Struma Ovarii is a very rare disease and there are various approaches to treatment based on staging. In our review, we found a higher rate of metastasis than previously reported. Recurrence was seen after an average period of 4 years. We recommend follow-up with surveillance thyroglobulin levels in cases of malignant Struma Ovarii for at least 10 years.
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2004.06.003