Gamma mode of infiltration associated with poor prognosis in malignant teratoma of the ovary: A case report

Although mature cystic teratoma is the most common tumor of the ovary, squamous cell carcinoma arising from a mature teratoma is a rare event. Prognosis depends on clinical stage, grade, and recently described mode of tumor infiltration. This case involves a 52-year-old woman with stage II squamous...

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Bibliographic Details
Published in:Gynecologic oncology 2005-07, Vol.98 (1), p.155-157
Main Authors: Spannuth, Whitney A., Rocconi, Rodney P., Kirby, Tyler O., Huh, Warner K., Conner, Michael G.
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Chemotherapy, Adjuvant
Female
Humans
Middle Aged
Neoplasm Staging
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Prognosis
Squamous cell carcinoma
Teratoma
Teratoma - drug therapy
Teratoma - pathology
Teratoma - surgery
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Summary:Although mature cystic teratoma is the most common tumor of the ovary, squamous cell carcinoma arising from a mature teratoma is a rare event. Prognosis depends on clinical stage, grade, and recently described mode of tumor infiltration. This case involves a 52-year-old woman with stage II squamous cell carcinoma arising in a mature cystic teratoma of the left ovary. Final pathology demonstrated poorly differentiated squamous cell carcinoma with gamma mode of tumor infiltration. The patient completed adjuvant chemotherapy and subsequently died of progressive disease. Squamous cell carcinoma arising from a benign cystic teratoma is a rare event. Studies have shown stage, grade, and mode of infiltration to be predictors of recurrence and prognosis. This case supports the growing evidence linking the mode of tumor infiltration with overall prognosis of survival.
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2005.04.011