Markers of the p53 pathway further refine molecular profiling in high-risk endometrial cancer: A Trans PORTEC initiative

Highlights • We used markers of the p53 pathway to refine existing stratifications of endometrial cancer. • We showed that mdm2 and p63 are useful markers to further classify this disease. • This is particularly important in the copy number low tumours.

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Bibliographic Details
Published in:Gynecologic oncology 2017-08, Vol.146 (2), p.327-333
Main Authors: Edmondson, R.J, Crosbie, E.J, Nickkho-Amiry, M, Kaufmann, A, Stelloo, E, Nijman, H.W, Leary, A, Auguste, A, Mileshkin, L, Pollock, P, MacKay, H.J, Powell, M.E, Bosse, T, Creutzberg, C.L, Kitchener, H.C
Format: Article
Language:English
Subjects:
Hematology, Oncology and Palliative Medicine
Obstetrics and Gynecology
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Summary:Highlights • We used markers of the p53 pathway to refine existing stratifications of endometrial cancer. • We showed that mdm2 and p63 are useful markers to further classify this disease. • This is particularly important in the copy number low tumours.
ISSN:0090-8258
DOI:10.1016/j.ygyno.2017.05.014