Statins inhibit reoxygenation-induced cardiomyocyte apoptosis: role for glycogen synthase kinase 3β and transcription factor β-catenin

Background. – Statins may improve left ventricular remodeling after myocardial infarction. We tested whether statins inhibit cardiomyocyte apoptosis through glycogen synthase kinase 3β (GSK3β) inactivation and evaluated activation of downstream transcription factors. Methods/results. – Mevastatin an...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2004-09, Vol.37 (3), p.681-690
Main Authors: Bergmann, Martin W., Rechner, Cindy, Freund, Christian, Baurand, Anthony, El Jamali, Amina, Dietz, Rainer
Format: Article
Language:English
Subjects:
Apoptosis
Cardiomyocyte
Glycogen synthase kinase 3β
Hypoxia
Transcription factor
β-catenin
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Summary:Background. – Statins may improve left ventricular remodeling after myocardial infarction. We tested whether statins inhibit cardiomyocyte apoptosis through glycogen synthase kinase 3β (GSK3β) inactivation and evaluated activation of downstream transcription factors. Methods/results. – Mevastatin and pravastatin activated serine/threonine kinase Akt in neonatal cardiomyocytes dose and time dependently with maximal activation at 15 min/10 μM. Caspase-3 activity was induced 2.73 ± 0.29-fold by 6 h of hypoxia followed by 18 h of reoxygenation. Pravastatin added at the beginning of the reoxygenation period reduced caspase-3 activation to 1.26 ± 0.06-fold compared to control cells ( P 
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2004.05.025