The zebrafish as a model system for assessing the reinforcing properties of drugs of abuse

Recent reports make use of the zebrafish to study complex behavior such as addiction, anxiety, or learning and memory. We have established reliable tests and appropriate controls to measure these behavioral parameters in the zebrafish adult. Our assays are robust enough to permit the detection of do...

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Bibliographic Details
Published in:Methods (San Diego, Calif.) Calif.), 2006-07, Vol.39 (3), p.262-274
Main Authors: Ninkovic, Jovica, Bally-Cuif, Laure
Format: Article
Language:English
Subjects:
Addiction
Animals
Aversion
Behavior
Behavior, Addictive - genetics
Conditioned place preference (CPP)
Conditioning (Psychology)
d-Amphetamine
Dextroamphetamine - toxicity
Disease Models, Animal
Learning and memory
Mutation
Reinforcement (Psychology)
Street Drugs - toxicity
Substance-Related Disorders - genetics
Toxicity Tests - instrumentation
Toxicity Tests - methods
Zebrafish
Zebrafish - genetics
Zebrafish - physiology
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Description
Summary:Recent reports make use of the zebrafish to study complex behavior such as addiction, anxiety, or learning and memory. We have established reliable tests and appropriate controls to measure these behavioral parameters in the zebrafish adult. Our assays are robust enough to permit the detection of dominant mutations affecting drug-induced reward, and therefore can be used in forward genetic screens. We provide the reader with the technical details of these tests, as well as their appropriate and crucial, although often overlooked, control assays. In particular, our results make it possible to use the zebrafish as a promising model to identify new genetic components of the reward pathway, or other measurable behaviors.
ISSN:1046-2023
1095-9130
DOI:10.1016/j.ymeth.2005.12.007