Measurement of cardiovascular and pulmonary function endpoints and other physiological effects following partial or complete substitution of cigarettes with electronic cigarettes in adult smokers

Acute changes in select physiological parameters associated with cardiovascular physiology (systolic and diastolic blood pressure (BP) and heart rate (HR)), pulmonary function (FVC, FEV1, and exhaled CO and NO) and adverse events were measured in 105 clinically confined subjects who were randomized...

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Bibliographic Details
Published in:Regulatory toxicology and pharmacology 2017-07, Vol.87, p.36-53
Main Authors: D'Ruiz, Carl D., O'Connell, Grant, Graff, Donald W., Yan, X. Sherwin
Format: Article
Language:English
Subjects:
Adult
Adverse effects
Blood Pressure - physiology
Cardiovascular effects
E-cigarette
Electronic Nicotine Delivery Systems
Exclusive and dual use
Forced Expiratory Flow Rates
Harm reduction
Heart Rate - physiology
Humans
Lung - physiopathology
Physiological effects
Pulmonary effects
Respiratory Function Tests
Smoking - physiopathology
Smoking Cessation
Tobacco Products
Tobacco Use Disorder
Vital Capacity
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Summary:Acute changes in select physiological parameters associated with cardiovascular physiology (systolic and diastolic blood pressure (BP) and heart rate (HR)), pulmonary function (FVC, FEV1, and exhaled CO and NO) and adverse events were measured in 105 clinically confined subjects who were randomized into groups that either completely or partially switched from conventional cigarettes to e-cigarettes or completely discontinued using tobacco and nicotine products altogether. Use of the e-cigarettes for five days under the various study conditions did not lead to higher BP or HR values, negative respiratory health outcomes or serious adverse health events. Reductions in BP and HR vital signs were observed in most of the participants that either ceased tobacco and nicotine products use altogether or switched completely to using e-cigarettes. Pulmonary function tests showed small but non-statistically significant improvements in FVC and FEV1 measurements in most use groups. Statistically significant (p 
ISSN:0273-2300
1096-0295
DOI:10.1016/j.yrtph.2017.05.002