Comparative effect of ochratoxin A on inflammation and oxidative stress parameters in gut and kidney of piglets

Ochratoxin A (OTA) is a secondary metabolite produced by fungi of Aspergillus and Penicillium genra. OTA is mainly nephrotoxic but can also cause hepatotoxicity, mutagenicity, teratogenicity, neurotoxicity and immunotoxicity. As recent studies have highlighted the close relationship between gastroin...

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Bibliographic Details
Published in:Regulatory toxicology and pharmacology 2017-10, Vol.89, p.224-231
Main Authors: Marin, Daniela E., Pistol, Gina C., Gras, Mihai A., Palade, Mihai L., Taranu, Ionelia
Format: Article
Language:English
Subjects:
Animals
Cytokines - metabolism
Gene Expression
Gut
Immune response
Inflammation - metabolism
Intestines - drug effects
Intestines - metabolism
Kidney
Kidney - drug effects
Kidney - metabolism
Ochratoxin A
Ochratoxins - administration & dosage
Ochratoxins - toxicity
Oxidative stress
Oxidative Stress - drug effects
Piglets
Random Allocation
Swine
Toxicity Tests, Subchronic
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Summary:Ochratoxin A (OTA) is a secondary metabolite produced by fungi of Aspergillus and Penicillium genra. OTA is mainly nephrotoxic but can also cause hepatotoxicity, mutagenicity, teratogenicity, neurotoxicity and immunotoxicity. As recent studies have highlighted the close relationship between gastrointestinal tract and kidney, as principal organs involved in absorption and respective excretion of xenobiotics, the aim of the present study was to analyze the effect of a subchronic exposure (30 days) to 0.05 mg/kg OTA on immune response and oxidative stress parameters at the level of intestine and kidney of young swine. The experiment was realised on twelve crossbred weaned piglets randomly allotted to both control group or toxin group fed 0.050 mg OTA/kg feed. Our results have shown that a subchronic intoxication with a low dose of OTA for 30 days affected the immune response and the anti-oxidant self-defense at gut and kidney level. The gene expression of both markers of signaling pathways involved in inflammation and inflammatory cytokines were affected in a much higher extent in the gut than in the kidney Of OTA intoxicated piglets. •Intoxication with low dose of OTA affect the immune response in gut and kidney.•Exposure to OTA low dose significantly decrease the Nrf2 expression in duodenum.•Inflammatory gene expression was more affected in gut than in kidney by OTA.
ISSN:0273-2300
1096-0295
DOI:10.1016/j.yrtph.2017.07.031