Interplay of gender, age and drug properties on reporting frequency of drug-induced liver injury

We examined the effect of gender, age, and drug properties on liver events reporting frequency (RF) to assess patient- and drug-related risks for drug-induced liver injury (DILI). We performed a data-mining analysis of the WHO VigiBase™ to 1) identify drugs with gender- and age-biased RF and 2) char...

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Bibliographic Details
Published in:Regulatory toxicology and pharmacology 2018-04, Vol.94, p.101-107
Main Authors: George, Nayana, Chen, Minjun, Yuen, Nancy, Hunt, Christine M., Suzuki, Ayako
Format: Article
Language:English
Subjects:
Drug property
Drug-induced liver injury
Gender differences
Hepatotoxicity
Liver events, and pharmacovigilance
Spontaneous adverse event reporting system
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Summary:We examined the effect of gender, age, and drug properties on liver events reporting frequency (RF) to assess patient- and drug-related risks for drug-induced liver injury (DILI). We performed a data-mining analysis of the WHO VigiBase™ to 1) identify drugs with gender- and age-biased RF and 2) characterize drug properties using the Liver Toxicity Knowledge Base. Age-, gender-specific Empirical Bayes Geometric Mean of relative reporting ratio of liver events with 90% confidence interval (CI) was calculated for 375 drugs with DILI potential. Forty-one drugs showed an increased RF in women, which had a higher prevalence of reactive metabolite formation and mitochondrial dysfunction and transporter inhibition. Fifty-nine drugs showed an increased RF in younger women (
ISSN:0273-2300
1096-0295
DOI:10.1016/j.yrtph.2018.01.018