Dermal exposure and hair dye: Assessing potential bladder cancer risk from permanent hair dye

• Published in: Regulatory toxicology and pharmacology 2023-02, Vol.138, p.105331, Article 105331
• Main Authors: More, Sharlee L., Fung, Ernest S., Mathis, Claire, Schulte, Alexandra M., Hollins, Dana
• Format: Article
• Language: English
• Subjects: 4-ABP; 4-Aminobiphenyl; Animals; Bladder cancer; Hair dye; Hair Dyes - toxicity; Humans; Margin of safety; Mice; Para-phenylenediamine; Phenylenediamines - toxicity; PPD; Quantitative risk assessment; Risk Assessment; Urinary Bladder - chemistry; Urinary Bladder Neoplasms - chemically induced
• ISSN: 0273-2300; 1096-0295
• DOI: 10.1016/j.yrtph.2022.105331

Hair dye products include a range of chemicals, depending on the type and color. A common primary intermediate compound used to achieve the permanent effect of hair dye is para-phenylenediamine (PPD). 4-aminobiphenyl (4-ABP) has reportedly been found as a trace contaminant (presumably from the para-phenylenediamine [PPD] ingredient) in consumer permanent hair dye. While several regulatory agencies have designated 4-ABP as a human bladder carcinogen based on evidence in humans and experimental animals, only the Office of Environmental Health Hazard Assessment (OEHHA) have established a cancer risk value for 4-ABP of 0.03 μg/day based on liver tumors developed in mice. A hypothetical dermal risk assessment was performed to estimate the bladder cancer risk associated with exposure to 4-ABP from personal use of permanent hair dye potentially containing incidental 4-ABP. Previously published laboratory analyses characterizing 4-ABP concentrations in consumer hair dyes indicate the concentrations can range from below the limit of detection to 8120 ppb. Precautionary estimates of human scalp surface area, maximum skin adherence, hair dye retention factor, and percent dermal absorption were used to estimate the daily systemic exposure doses (SEDs) from dermal application of hair dye. The estimated SEDs ranged from 0.05 to 3000 pg/day. A margin of safety (MOS) was calculated as the ratio of the NSRL to the SED and ranged from 10 to 570,000. The results of this study suggest that there is no indication of increased risk of bladder cancer in humans from exposure to 4-ABP in consumer hair dye, especially as it is extremely unlikely that a consumer would use permanent hair dye on a daily basis (as this assessment models). •4-ABP has reportedly been found as a trace contaminant in permanent hair dye.•Assess whether dermal exposure to 4-ABP in hair dye increases risk of bladder cancer.•Application of contaminated hair dye would not increase the risk of bladder cancer.