Filaricidal properties of a wild herb, Andrographis paniculata

Water decoction of the leaves of Andrographis paniculata killed in vitro the microfilaria of Dipetalonema reconditum in 40 min. Three subcutaneous injections of the extract into infected dogs at 0·06 ml per kg bodyweight reduced the number of microfilariae in blood by more than 85%. The larvae were...

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Bibliographic Details
Published in:Journal of helminthology 1982-06, Vol.56 (2), p.81-84
Main Authors: Dutta, Anita, Sukul, Nirmal C.
Format: Article
Language:English
Subjects:
Animals
Anthelmintics
Dipetalonema Infections - drug therapy
Dipetalonema Infections - parasitology
Dogs
Drug Evaluation, Preclinical
Female
Filaricides - therapeutic use
Filaricides - toxicity
India
Male
Microfilariae - drug effects
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Extracts - toxicity
Plants, Medicinal
Rabbits
Research Papers
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Summary:Water decoction of the leaves of Andrographis paniculata killed in vitro the microfilaria of Dipetalonema reconditum in 40 min. Three subcutaneous injections of the extract into infected dogs at 0·06 ml per kg bodyweight reduced the number of microfilariae in blood by more than 85%. The larvae were not totally eliminated with more infections but the reduced microfilarial level persisted. No toxiceffect of the extract was observed in rabbits. The treated dogs became lethargic initially for a week, probably due to the mass killing of microfilariae.
ISSN:0022-149X
1475-2697
DOI:10.1017/S0022149X0003426X