Hypersensitivity in cattle after foot -and -mouth disease vaccination: response to hydroxypropylmethylcellulose

Intravenous provocation (IVP) tests demonstrated that hydroxypropylmethylcellulose (MC) was able to elicit anaphylactic signs in cattle vaccinated with foot-and-mouth disease (FMD) vaccine produced at one centre but not with similar vaccine produced at another. The former vaccine also provoked serum...

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Bibliographic Details
Published in:The Journal of hygiene 1975-08, Vol.75 (1), p.79-86
Main Authors: Black, L., Menard, F. J. R. R., Beadle, G. G., Pay, T. W. F.
Format: Article
Language:English
Subjects:
Allergies
Anaphylaxis
animal diseases
animal health
Cell growth
Foot and mouth disease
Hypersensitivity
Injections
Passive cutaneous anaphylaxis
Principal components analysis
Ungulates
Vaccination
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Summary:Intravenous provocation (IVP) tests demonstrated that hydroxypropylmethylcellulose (MC) was able to elicit anaphylactic signs in cattle vaccinated with foot-and-mouth disease (FMD) vaccine produced at one centre but not with similar vaccine produced at another. The former vaccine also provoked serum reagins which were demonstrated by passive cutaneous anaphylaxis (PCA) tests in goats. Reaginic sera which reacted specifically with MC were used in PCA tests to screen samples taken serially from the vaccine production lines. The reactions observed suggested that a substance with MC or similar specificity was present in the antifoaming agent routinely added to vaccines.
ISSN:0022-1724
2396-8184
DOI:10.1017/S0022172400047082